The purpose of this research is to evaluate the effect of general anesthesia on liver and kidney functions by comparing the pre- and postoperative values of 50 patients. It was found that liver enzymes, including ALT, AST, and ALP, and renal function tests, including urea and creatinine, increased significantly. It is suggested that this is a result of the metabolism of the drugs used for general anesthesia and the physiological stress of the surgery. It is noted that although this is a transient effect, this is a demonstration of the potential for a short-term stress on the liver and a decrease in renal function. It is suggested that this is a result of drug toxicity, changes in organ perfusion, and the acute phase response to surgery. It is noted that this is a demonstration of the need for constant monitoring and selection of drugs used for general anesthesia.